Xeomin vs Botox – What’s the Difference?
Xeomin is an anti-wrinkle injectable used to temporarily improve and soften the look of wrinkles by relaxing the facial muscles to soften lines around the eyes, forehead, and mouth. Xeomin contains botulinum toxin type A, a protein purified from the bacterium Clostridium botulinum.
Botox—another injectable that works to reduce wrinkle & fine lines—is also made from botulinum toxin type A, but Xeomin differentiates itself from Botox and other anti-wrinkle injectables by omitting accessory proteins. So the main difference between Xeomin and Botox is that Xeomin contains a “naked” form of botulinum toxin.
Unlike Botox, which contains accessory proteins, Xeomin is designed to deliver the product without any protein additives. In Botox and other injectables, those accessory proteins help to stabilize the molecules of botulinum toxin, and aren’t essential to its function.


There’s a theory that those accessory proteins may trigger an immune response in your body to the product—and that Xeomin’s omission of those proteins may help protect against that. This purified structure may help prevent antibody resistance, a growing problem that has been seen with injections administered over time.
So Xeomin has the same effect as Botox to relax the muscle and the company-sponsored studies show that it is not inferior to Botox and has similar efficacy.